Figure 5. Blocking effects of PD98059, SeCl4 and MK-0524 on dexamethasone pretreatment-induced neuroprotection against hypoxic-ischemic (HI) brain injury in P10 rat pups.
Dexamethasone was injected into the right lateral ventricle in day 10 (P10) pups before HI-induced brain injury in the absence or presence of the MEK1 inhibitor (PD98059), L-PGDS inhibitor (SeCl4) or DP1 antagonist (MK-0524). Infarct size at the ipsilateral brain hemisphere was measured via TTC staining (shown by arrows), and reported as percent of the whole brain. Data are mean ± SEM, n = 6 each group. Statistical significance was determined by Student t-test between saline control and dexamethasone treatment groups. *p<0.05 dexamethasone versus saline control.