Figure 6. Trial sequential analysis of all-cause mortality in patients with septic shock.

Trial sequential analyses assessing the effect of albumin on all-cause mortality in 3 studies. The diversity-adjusted required information size (4586 participants) was based on a relative risk reduction of 10%; an alpha of 5%; a beta of 2% and an event proportion of 40.3% in the control arm. The blue cumulative z curve was constructed using a random effects model.