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A –C: Examples of Western blots for between-group comparison of 2N Veh vs. Ts Veh, 2N Veh vs. 2N JZL, and Ts Veh vs. Ts JZL. D –F: Quantification of the data. Levels of App were increased, while the levels of BACE1 were not altered in the vehicle-treated Ts65Dn vs. 2N brain (A, D). Treatment with JZL184 had no effect on the expression levels of these proteins in either 2N (B, E) or Ts65Dn (C, F).
