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. 2014 Dec 4;10(12):e1004550. doi: 10.1371/journal.ppat.1004550

Figure 6. Blocking JAM-C enhances DC migration and boosts the immune responses to L. major infection.

Figure 6

By removing JAM-C out of functions, H33 increases adhesion of leukocytes and potentiates vascular permeability and cell migration of leukocytes after L. major infection. Increased numbers of recruited neutrophils result in higher levels of the chemokine CCL3 attracting monocytes and mo-DCs in C57BL/6 mice. The number of migratory DCs to lymph nodes increases, and the subsequent T cell response is mounted more efficiently. Resistant C57BL/6 mice develop a higher IFN-γ-dominated Th1 response while susceptible BALB/c mice develop a stronger IL-4-dominated Th2 response. This has a significant healing effect in resistant animals whereas susceptible mice display an exacerbated disease.