HP1BP3-dependent modulation of cancer cell adhesion during hypoxia. A431 cells were subjected to 48 h normoxia (Nx), 48 h hypoxia (Hx), or 24 h hypoxia followed by 24 h re-oxygenation (Rx) and then assessed for adhesion to collagen- (A), laminin- (B), and fibronectin-based (C) matrices. Each experiment was performed at least in triplicate (*p < 0.05, **p < 0.005).