Table I. Summary of rankings assigned to IFNs and TNF-α in IPA reports of upstream regulators of significance in A549 cell responses to hRSV infection.

Cytokine	Features		Representative target moleculesc
	Rankinga	Conformityb
IFNG	1	80 of 83	DDX58, IFIT1, IFIT2, IFIT3, ISG15, ISG20, MX1, PSMB9, SAMHD1, WARS
IFNA2	3	45 of 46	DDX58, IFIT1, IFIT2, IFIT3, ISG15, ISG20, MX1, SAMHD1
IFNL1	4	33 of 33	DDX58, IFIT1, IFIT2, IFIT3, ISG15, ISG20, MX1, PSMB9
IFN alpha	8	40 of 47	DDX58, IFIT1, IFIT2, IFIT3, ISG15, ISG20, MX1, PSMB9, WARS
TNF	9	72 of 82	DDX58, IFIT1, IFIT3, ISG15, MX1, PSMB9
IFNB1	26	20 of 26	DDX58, IFIT1, IFIT2, IFIT3, ISG15, MX1

^a Order of appearance in the list of upstream regulators reported by IPA.

^b Indicates the number of regulated protein group associated gene names which conformed to the direction of regulation predicted by IPA.

^c Subset of the target molecules reported by IPA.