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. 2014 Sep 9;13(12):3421–3434. doi: 10.1074/mcp.M114.040121

Fig. 6.

Fig. 6.

Quantification of renal mRNA expression of enzymes of the ≪Arginase pathway≫ and modification of the l-Arginine metabolism during UUO. A, Real-time PCR quantification of mRNA levels of Ornithine aminotransferase (Oat), P5C synthase, (P5cs), P5C reductase (P5cr), Ornithine decarboxylase (Odc), P5C dehydrogenase (P5cd), and Proline dehydrogenase (Prodh) genes in mouse kidneys from control mice or from mice obstructed for 3 or 8 days (n = 8/group). B, Real-time PCR quantification of mRNA levels of genes involved in the l-Arginine metabolism in kidneys from control and 3 or 8 days-obstructed mice (n = 8/group). Arginine succinate synthase (Ass) and Arginine succinate lyase (Asl) are enzymes responsible for cellular l-arginine production. Cationic amino acid transporters (Cat 1–2) allow l-arginine transport in cells. C, Measurement of plasma arginine (μmol/L) during UUO (n = 4/group). Values are represented as means ± S.D. Mann-Whitney test p value: *<0,05; **<0,01; ***<0,001.