Fig. 1.
Synchronization of fragment ion mobility and pusher frequency improves the system performance of a Q-TOF instrument. A, Schematic illustration of operation of conventional DDA (above dashed line) and HD-DDA (below dashed line) on a Q-TOF instrument. B, Tandem mass spectrum of GluFib without (-) and with (+) fragment ion mobility synchronization enabled. The insert shows the 10x magnified tandem mass spectrum of the conventional DDA experiment.