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Study design and dose escalation schedule. Blue arrows represent dosing; black arrows represent pharmacokinetic, pharmacodynamic, immunogenicity, safety and/or effect assessment visits. Numbers in parenthesis indicate AMG 181: placebo randomization ratio per study protocol and the number of subjects (N) completing the study. s.c. = subcutaneous; i.v. = intravenous; UC = ulcerative colitis subjects else, healthy subjects
