Figure 8.
Individual profiles in ulcerative colitis subjects: AMG 181 concentration (left y-axis; PK) and pre-dose baseline-normalized rate of free α4β7 receptor on CD4+ naïve T cells (right y -axis; PD) (A), CD4 + central memory T cell (Tcm) count (B), total (large symbols only) and partial (small symbols with lines connected) Mayo score (C), serum C-reactive protein (D), fecal calprotectin (E) and lactoferrin (F) presented as observed (symbols) and median (lines). Note: Subject 4 was on placebo; others were on 210 mg AMG 181s.c. (A) PK: 
, Subject 1; 
, Subject 2; 
, Subject 3; 
, Subject 4 PD: 
, Subject 1; 
, Subject 2; 
, Subject 3; 
, Subject 4. (B and D) 
, Subject 1; 
, Subject 2; 
, Subject 3; 
, Subject 4. (C) Mayo: 
, Subject 1; 
, Subject 2; 
, Subject 3; 
, Subject 4 Partial Mayo: 
, Subject 1; 
, Subject 2; 
, Subject 3; 
, Subject 4 
, 
, 
, 
. (E and F) 
, Subject 1; 
, Subject 2; 
, Subject 3; 
, Subject 4; 
, 
, 
, 