Table 3.
Summary of statistical analysis of the change from placebo in cerebral blood flow velocity in PCA, BA and MCA in response to hypercapnia at day 28
| Parameters | Statistics | Fingolimod 0.5 mg | Fingolimod 1.25 mg | |
|---|---|---|---|---|
| n = 30 | n = 29 | |||
| Reference value* | ||||
|
PCA (cm s−1) |
7.24 | n | 30 | 29 |
| LS mean | 34.39 | 37.11 | ||
| Difference (95% CI) | −1.09 (−3.69, 1.5) | 1.62 (−0.99, 4.24) | ||
| Conclusion | Non-inferior | Non-inferior | ||
|
BA (cm s−1) |
6.84 | n | 30 | 29 |
| LS mean | 33.01 | 33.66 | ||
| Difference (95% CI) | −0.49 (−2.87, 1.89) | 0.15 (−2.25, 2.55) | ||
| Conclusion | Non-inferior | Non-inferior | ||
|
MCA CO2 reactivity index (%mmHg) |
1.00 | n | 30 | 29 |
| LS mean | 4.95 | 5.05 | ||
| Difference (95% CI) | −0.04 (−0.16, 0.08) | 0.06 (−0.06, 0.18) | ||
| Conclusion | Non-inferior | Non-inferior |
*
Reference value: 20% of mean baseline value. CI, confidence interval; LS mean, least square mean; MCA, middle cerebral artery; PCA, posterior cerebral artery; BA, basilar artery.