Table 3.
Level of expression energy metabolism-related proteins in the femoral artery
| Protein | Control (AU) | FXa (AU) | FXa + rivaroxaban (AU) | |
|---|---|---|---|---|
| Energetic metabolism | Fructose 1,6-bisphosphate aldolase | 18.32 ± 7.6 | 19.65 ± 6.43 | 12.00 ± 4.80 |
| Triosephosphate isomerase | ||||
| Isoform 1 | 7.80 ± 2.46 | 13.34 ± 3.68* | 6.23 ± 1.79** | |
| Isoform 2 | 8.20 ± 3.12 | 29.75 ± 6.60* | 13.55 ± 5.82 | |
| Glyceraldehyde-3-phosphate dehydrogenase | ||||
| Isoform 1 | 8.91 ± 3.12 | 19.28 ± 5.35* | 7.19 ± 2.71** | |
| Isoform 2 | 28.4 ± 9.13 | 19.23 ± 6.27 | 26.46 ± 13.98 | |
| Isoform 3 | 39.08 ± 16.05 | 33.45 ± 14.79 | 20.10 ± 13.26 | |
| Phosphoglycerate kinase | ||||
| Isoform 1 | 16.20 ± 4.64 | 16.00 ± 6.31 | 18.50 ± 4.24 | |
| Isoform 2 | 10.88 ± 4.04 | 9.60 ± 3.23 | 16.52 ± 4.68 | |
| Phosphoglycerate mutase | 12.87 ± 4.21 | 14.94 ± 9.87 | 13.73 ± 3.41 | |
| Alpha-enolase | 13.78 ± 3.48 | 13.06 ± 4.84 | 8.27 ± 1.90 | |
| Gamma enolase | 15.48 ± 4.24 | 16.57 ± 4.15 | 13.20 ± 3.74 | |
| Pyruvate kinase | 15.90 ± 4.05 | 24.27 ± 5.56 | 15.07 ± 2.09 | |
| Lactate dehydrogenase | 17.20 ± 5.59 | 16.14 ± 3.77 | 15.84 ± 4.83 | |
| Aconytate hydratase | 12.13 ± 3.46 | 15.99 ± 3.11 | 15.35 ± 1.96 | |
| Mitochondrial precursor acyl CoA dehydrogenase | ||||
| Isoform 1 | 6.40 ± 1.91 | 9.79 ± 3.54 | 5.79 ± 1.46 | |
| Isoform 2 | 5.22 ± 1.46 | 5.39 ± 1.42 | 4.54 ± 0.84 | |
| Creatine kinase M chain | 13.39 ± 4.37 | 33.96 ± 7.96* | 15.16 ± 3.45** |
*
P < 0.05 with respect to control.
**
P < 0.05 with respect to FXa alone. The results are represented as mean ± SEM. AU, arbitrary units.