Table 2.
Population pharmacokinetic parameters of FTC from the final model
| Parameter | Estimate | RSE (%) |
|---|---|---|
| Structural model | ||
| ka (h−1) | 0.616 | 32 |
| CL/F (l h−1) | 22.3 | 3 |
| Vc/F (l) | 100 | 16 |
| Q/F (l h−1) | 5.89 | 22 |
| Vp/F (l) | 76.1 | 28 |
| βCLcr on CL/F | 0.33 | 16 |
| Statistical model | ||
| η ka | 0.503 | 36 |
| η CL/F | 0.151 | 14 |
| σ1 | 0.505 | 6 |
| σ2 | 0.373 | 6 |
RSE, relative standard error; ka, absorption rate constant; CL/F, apparent elimination clearance; Vc/F, apparent central volume of distribution; Q/F, apparent intercompartmental clearance; Vp/F, apparent peripheral volume of distribution; βCLcr on CL/F, influential factor of creatinine clearance on CL/F; η, interindividual variability; σ1, residual variability estimate for therapeutic drug monitoring study; σ2, residual variability estimate for TEmAA ANRS 12109 study.