Gender-specific effect of GPER P16L expression on blood pressure in normotensive subjects. (A) Mean arterial blood pressure, (B) systolic blood pressure or (C) diastolic blood pressures were significantly higher in females, but not males, carrying the GPER P16L variant (V). * represents P < 0.05 vs. wild type. , WT (females = 204, males = 108); , P16L (females = 127, males = 68)