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. 2014 Dec 5;4:7330. doi: 10.1038/srep07330

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(A) and (B) INPP5F overexpressing cells were lysed and immunoprecipitated with anti-V5 for INPP5F and anti-STAT3. Immunoblot analysis represents that INPP5F interacts with STAT3 in both cell lines with overexpressed INPP5F. (C) IP was performed with anti-V5 for INPP5F and immunoblot analysis represents that dominant negative STAT3 (Y705F) interacts with INPP5F in 293T cells. (D) Schematic diagrams of the structural domains and deletion mutants of STAT3. (E) Serial mutants of STAT3 and INPP5F were co-transfected in 293T cells and immuneprecipitated with anti-V5 for INPP5F. Immunoblot analysis represents that INPP5F interacted with full-length and deleted N-terminal domain of STAT3. Anti-GFP is used for STAT3 (Y705F) and its serial mutants, and anti-V5 for INPP5F.