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. Author manuscript; available in PMC: 2014 Dec 5.
Published in final edited form as: Nat Neurosci. 2014 May 25;17(7):971–980. doi: 10.1038/nn.3728

Figure 3.

Figure 3

FTY720-P inhibits class I HDACs. (a–d) HDAC activities of recombinant class I HDACs (HDAC1, 2, 3 and 8) and (e) class II HDAC (HDAC7) were measured in the presence of vehicle, S1P (5 μM), FTY720-P (0.5 or 5 μM), FTY720 (5 μM) or SAHA (2 μM). Data are averages of triplicate determinations ±s.d. and expressed as arbitrary fluorescence units (AFU). *P < 0.0001 as compared to vehicle (N = 3 independent samples per group); one-way ANOVA with Bonferroni multiple-comparisons test. Insets, proteins analyzed by western blotting with HDAC-specific antibodies.