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. 2014 Nov 27;15:53. doi: 10.1186/s12865-014-0053-0

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© Buschmann et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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RAGE- and ICAM-1-dependent fetal neutrophil adhesion. Neutrophil adhesion of preterm and term infants and adults was analyzed in dynamic microflow chamber experiments (A) Neutrophil adhesion upon P-selectin, IL-8 and ICAM-1 was compared between the various age groups and to respective uncoated controls. (B) Neutrophil adhesion is shown for P-selectin and IL-8 coated flow chambers with and without ICAM-1. (C) ICAM-1-and sRAGE-dependent neutrophil adhesion in combination with P-selectin and IL-8-coating. Results are presented as mean + SEM from at least 5 separate individuals/experiments per group. Significant differences (p <0.05) to uncoated or P-selectin and IL-8 coated flow chambers are indicated by asterisks and by the pound key (as indicated).