Table 1.
List of genes induced or suppressed in the chicken caecum 4 days after infection of newly hatched chickens with Salmonella Enteritidis
| Gene | Name | Function | Cell | Protein | RNA | Ref. |
|---|---|---|---|---|---|---|
| GENES UPREGULATED IN THE CHICKEN CECUM | ||||||
| MMP7 | matrix metallopeptidase 7 | degradation of extracellular matrix proteins | Ep | ND | 1430.8 | [12] |
| MUC2L | mucin-2-like | mucus production | Ep | ND | 4.02 | [12] |
| IFIT5 | interferon-induced protein with tetratricopeptide repeats 5 | uncapped RNA binding and inactivation | unknown | ND | 6.75 | [12] |
| ES1 | ES1 protein homolog | unknown | unknown | 25.8 | 28.30 | [12] |
| IL8 | interleukin 8 | chemokine | Ep, M | ND | 5.36 | [12] |
| iNOS | inducible NO synthase | NO radical production using arginine as a substrate | M, T, B | ND | 37.09 | [12] |
| ExFABP | extracellular fatty acid binding protein | fatty acid and bacterial siderophore binding | Ht, M | ND | 151.6 | [12] |
| MRP126 | MRP-126, S100A9, calprotectin, calgranulin | calcium and zinc binding | Ht, M | 312 | 42.57 | [12] |
| SERPINB10 | serpin peptidase inhibitor | protection of tissues against own proteases | Ht, M | 1313 | 30.95 | [12] |
| TRAP6 | trappin 6-like | protection of tissues against own proteases | Ht, M | ND | 36.46 | [37] |
| IRG1 | immune responsive gene 1 | itaconic acid and reactive oxygen species production | Ht, M | ND | 83.17 | [37] |
| SAA | serum amyloid A | acute phase protein, LPS binding | Ht, M | ND | 84.63 | [37] |
| C1QA | complement C1a component | complement | Ht, M | ND | 3.23 | [37] |
| C1QB | complement C1b component | complement | Ht, M | ND | 1.28 | [37] |
| C1QC | complement C1c component | complement | Ht, M | ND | 3.00 | [37] |
| C3 | complement 3 | complement | Ht, M | 81.4 | 10.78 | [12] |
| AVD | avidin | biotin binding, tissue reparation | M | ND | 15.15 | [37] |
| ASL2 | argininosuccinate lyase | arginine recycling | M | 12.2 | 4.36 | [12] |
| IL1B | interleukin 1 β | cytokine | M | ND | 28.09 | [12,32,38] |
| IL18 | interleukin 18 | cytokine | M | ND | 5.39 | [32,38] |
| CATHL2 | cathelicidin-2 | antimicrobial peptide | Ht | 317 | 2.15 | [12] |
| CATHL3 | cathelicidin-3 | antimicrobial peptide | Ht | ND | 1.50 | [12] |
| GAL1 | gallinacin-1 | antimicrobial peptide | Ht | ND | 0.70 | [32] |
| GAL2 | gallinacin-2 | antimicrobial peptide | Ht | ND | 1.22 | [32] |
| LYG2L | lysozyme G-like 2 | antimicrobial peptide | Ht | 283 | 37.21 | [12] |
| PGDS | prostaglandin D2 synthase | prostaglandin D2 synthesis | Ht | ND | 10.42 | [12] |
| RSFR | leukocyte ribonuclease A-2 | angiogenesis, antimicrobial peptide, ribonuclease | Ht | 915 | 5.70 | [12] |
| TGM3 | transglutaminase 3 | protein cross-linking | Ht | 643 | 2.76 | [12] |
| IgY | immunoglobulin Y heavy chain | antigen binding | B | ND | 8.51 | [37] |
| IgA | immunoglobulin A heavy chain | antigen binding | B | ND | 3.50 | [37] |
| IgM | immunoglobulin M heavy chain | antigen binding | B | ND | 3.91 | [37] |
| IgL | immunoglobulin light chain | antigen binding | B | ND | 7.09 | [37] |
| TGM4 | glutamine γ-glutamyltransferase 4 | protein crosslinking | B, M | 484 | 24.63 | [12] |
| IL17 | interleukin 17 | cytokine | T | ND | 5.43 | [12,32,38] |
| IL22 | interleukin 22 | cytokine | T | ND | 63.18 | [12,32,38] |
| IFNG | interferon γ | cytokine | T | ND | 32.08 | [12,32,38] |
| NKL | NK-lysin | lysis of own aberant cells | T | ND | 16.73 | unpubl. |
| GENES DOWNREGULATED IN THE CHICKEN CAECUM | ||||||
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | inactivation of prostaglandin D2 | unknown | ND | 4.0 | [12] |
| LOC769608 | uncharacterized oxidoreductase | unknown | unknown | 2.77 | 4.3 | [12] |
| ALDOB | aldolase B, fructose-bisphosphate | unknown | unknown | 2.64 | 4.6 | [12] |
| CALB1 | calbindin 1 | calcium transport | Ep | 2.26 | 5.5 | [12] |
| SULT1C3 | sulfotransferase | solubilasation and detoxification | unknown | ND | 6.2 | [12] |
| RALDH1 | aldehyde dehydrogenase 1 | unknown | unknown | 2.74 | 7.9 | [12] |
| FABP1 | fatty acid binding protein 1 | fatty acid transport | Ep | 2.92 | 8.3 | [12] |
| AQP8 | aquaporin 8 | water, ammonia and hydrogen peroxide transport | Ep | ND | 9.9 | [12] |
| ADH1B | alcohol dehydrogenase 1B | unknown | unknown | 4.52 | 13.2 | [12] |
Ep, epithelial cell, Ht – heterophil, M – macrophage, B – B lymphocyte, T – T lymphocyte, protein – fold induction or suppression determined by protein mass spectrometry, RNA – fold induction or suppression determined by real-time PCR, ND – not determined.