Table 2.

Association of RFC4 protein expression with clinicopathologic characteristics in CRC

Characteristics	Cases	RFC4 expression		P value
		Normal expression	Overexpression
Sex				0.059
Female	147	59 (40.1%)	88 (59.9%)
Male	184	93 (45.9%)	91 (54.1%)
Age				0.301
≤60	167	72 (43.1%)	95 (56.9%)
>60	164	80 (48.8%)	84 (51.2%)
Tumor location				0.344
Colon	154	75 (48.7%)	79 (51.3%)
Rectal	177	77 (43.5%)	100 (56.5%)
Differentiation				0.004
Well/Moderate	299	145 (48.5%)	154 (51.5%)
Poorly	32	7 (21.9%)	25 (78.1%)
Preoperative CEA level				0.656
< 5 ng/ml	194	89 (45.9%)	105 (54.1%)
≥ 5 ng/ml	111	48 (43.2%)	63 (56.8%)
Preoperative CA19-9 level				0.560
< 37 U/ml	238	109 (45.8%)	129 (54.2%)
≥37 U/ml	67	28 (41.8%)	39 (58.2%)
pT (invasion depth)				0.479
T1	6	1 (16.7%)	5 (83.3%)
T2	54	27 (50.0%)	27 (50.0%)
T3	233	106 (45.5%)	127 (54.5%)
T4	38	18 (47.4%)	20 (52.6%)
pN (lymph node metastasis)				0.055
N0	197	99 (49.2%)	98 (50.8%)
N1-2	134	53 (46.3%)	81 (53.7%)
pM (distant metastasis)				0.795
M0	299	138 (46.2%)	161 (53.8%)
M1	32	14 (43.8%)	18 (56.2%)
TNM stage				0.036
I + II	193	98 (50.8%)	95 (49.2%)
III + IV	138	54 (39.1%)	84 (60.9%)