Table 3.
Univariate and multivariate analysis for overall survival in CRC tissue microarray
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) | P | Hazard ratio (95% CI) | P | |
| Sex | ||||
| Female | 1 | 0.950 | ||
| Male | 1.013 (0.670-1.533) | |||
| Age | ||||
| ≤60 | 1 | 0.222 | ||
| >60 | 1.294 (0.855-1.958) | |||
| Tumor location | ||||
| Colon | 1 | 0.061 | ||
| Rectal | 1.502 (0.982-2.298) | |||
| Differentiation | ||||
| Well + Moderate | 1 | <0.001 | 1 | 0.016 |
| Poorly | 2.736 (1.593-4.699) | 1.945 (1.132-3.340) | ||
| Preoperative CEA level | ||||
| < 5 ng/ml | 1 | <0.001 | 1 | 0.022 |
| ≥ 5 ng/ml | 2.480 (1.590-3.866) | 1.741 (1.084-2.797) | ||
| Preoperative CA19-9 level | ||||
| < 37 U/ml | 1 | <0.001 | 1 | 0.014 |
| ≥37 U/ml | 2.553 (1.614-4.038) | 1.825 (1.127-2.954) | ||
| pT | ||||
| T1 + T2 | 1 | 0.169 | ||
| T3 + T4 | 1.532 (0.834-2.813) | |||
| pN | ||||
| N0 | 1 | <0.001 | ||
| N1-2 | 2.438 (1.609-3.696) | |||
| pM | ||||
| M0 | 1 | <0.001 | ||
| M1 | 7.502 (4.701-11.971) | |||
| TNM stage | ||||
| I + II | 1 | <0.001 | 1 | 0.006 |
| III + IV | 2.460 (1.618-3.741) | 1.933 (1.210-3.089) | ||
| RFC4 expression | ||||
| Normal | 1 | 0.011 | 1 | 0.366 |
| High | 1.745 (1.136-2.680) | 1.246 (0.774-2.005) | ||