Figure 8.

Graphical summary of results. Collectively, our data reveal the lPBN as a neural substrate for the feeding and body weight suppression effect of GLP-1 and identify the mechanisms involved. Elements of this novel energy balance relevant circuit identified in the current study are indicated in red. In contrast to the excitatory GLP-1 projections to the PBN, the projections from the hypothalamus (green) to the PBN provide inhibitory inputs, and their activation results in an orexigenic response.