Physiologic parameters during tumor progression in male and female nude mice after sc injection of 2 × 106 MPC-mCherry cells. A–D, Urinary concentration of free monoamines −10 and −2 d before, and 6, 13, 20, and 27 d after cell injection; presented as mean ± SD (male animals, n = 10, female animals, n = 10). E, Changes in the urinary concentration pattern of free monoamines (net chart) presented as mean (male + female animals, n = 20). F, Systolic BP −10 and −4 d before and 3, 10, 17, 24, 31 d after cell injection presented as mean (male animals, n = 10; female animals, n = 10) and mean ± SD (male + female animals, n = 20); DA, dopamine; MTY, 3-methoxytyramine; NE, norepinephrine; NMN, normetanephrine; EPI, epinephrine; MN, metanephrine; p.i., post injection. **, P < 0.01; ***, P < 0.001.