Table 3.

Core of substrates of the Dot/Icm secretion system present in 11 Legionella genomes

Label	Product and associated motif	Gene name	Amino acid identity a
			L. fallonii	L. long.	L. micdadeii	L. hack
lpg0021/lpp0021	Protein of unknown function [ribosome associated protein]		75	75	68	68
lpg0103/lpp0117	N-terminal acetyltransferase, GNAT family	vipF	62	61	50	47
lpg0107/lpp0121 b	Conserved protein of unknown function	ravC	84	80	72	47
lpg0140/lpp0155	Membrane protein of unknown function	cetLP1	53	45	39	36
lpg0376/lpp0443	Protein of unknown function	sdhA	60	48	38	38
lpg0405/lpp0471	Protein of unknown function		56	56	50	40
lpg0483/lpp0547	Protein of unknown function [ankyrin]c	legA12/ankC	55	49	31	29
lpg1356/lpp1310	Putative Beta-lactamase [Sel1-domain]c[TPR repeat]c	EnhC homologue	80	71	67	69
lpg1578/lpp4178	Protein of unknown function		50	37	25	24
lpg1661/lpp1632	Heparan-alpha glucosaminide N-acetyltransferased		60	57	47	48
lpg1663/lpp1634	Protein of unknown function	cetLP3	54	44	40	58
lpg1752/lpp1716	Protein of unknown function	mavB	41	40	27	26
lpg1907/lpp1882	Membrane protein of unknown function [hydrolases]		54	52	44	49
lpg2300/lpp2248	Protein of unknown function [ankyrin]c	legA3/ankH/ankW	81	76	71	75
lpg2322/lpp2270	Protein of unknown function [ankyrin]	legA5/ankK	57	51	39	42
lpg2351/lpp2300	Protein of unknown function	mavF	56	50	33	33
lpg2359/lpp2308	Protein of unknown function [putative GatB/Yqey domain]c		82	79	73	72
lpg2588/lpp2947	Acid sphingomyelinase-like phosphodiesterase	legS1	64	61	54	33
lpg2591/lpp2644	Protein of unknown function	ceg33	46	47	34	26
lpg2815/lpp2867	Membrane protein of unknown function	mavN	62	64	54	52
lpg2832/lpp2889	Protein of unknown function		72	68	60	62
lpg2888/lpp2947	Membrane protein of unknown function [coiled-coil]c		59	50	34	40
lpg2936/lpp3004	Ribosomal RNA small subunit methyltransferase E		67	67	60	60
lpg2975/lpp3047	Protein of unknown function	mavQ	58	57	33	30

^aAmino acid identity with respect to L. pneumophila strain Philadelphia. ^b ravC has been erroneously named as lpg0170 in previous publications. ^cThe motif is present in all orthologues. ^dHigh prediction for enzymatic activity in all the corresponding orthologues (prediction based on PRIAM EC number). Bold numbers indicate synteny between L. pneumophila genes and the corresponding orthologous gene.