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. 2014 Dec 3;15(12):522. doi: 10.1186/s13059-014-0522-z

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© Hall et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Impact of sex on DNA methylation and/or expression in human pancreatic islets of selected candidate genes. (A) DUSP9, a candidate gene for type 2 diabetes, is located on the X chromosome and has numerous differentially methylated CpG sites between female and male human pancreatic islets. (B-D) Impact of sex on the DNA methylation level of CpG sites and gene expression of NKAP (B), APLN (C) and SPESP1 (D). Data are presented as mean ± standard error of the mean. Asterisks indicate q <0.05 for DNA methylation and P <0.05 for expression