Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Aug 27;21(1):85. doi: 10.1186/s12929-014-0085-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Incani et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

AIRE is deacetylated by theHDAC1-2/SIN3A complex. COS-1 cells were transfected with AIRE-HALO and/or HDAC1 and/or HDAC2 with endogenous SIN3A. Immunoprecipitation was performed on lysates using antibodies against HALO. Panel A: Anti-acetyl lysine signal of anti-HALO-AIRE immunoprecipitation. Panel B: The plot shows densitometric analysis using Image J. The acetylation level of AIRE was reduced by 71% in the presence of HDAC1 and 48% in the presence of HDAC2. Value are means ± SD (n = 2).