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The transactivation of AIRE is regulated by HDAC inhibition. Values represent the relative luciferase activity (±SD) compared to the reporter plasmid transfected alone in the absence and in the presence of 5 mM NaBu. The ability of AIRE pbind -GAL4 to activate the gene reporter pGL5 was increased by four-fold in the presence of 5 mM NaBu. (n = 2), *P < 0.05.
