Table 2.
Characteristics of patients undergoing ECMO and controls
| ECMO (n = 11) | Controls (n = 11) | |
|---|---|---|
| Male, n | 4 | 5 |
| Age, years | 43 (19 to 59) | 55 (24 to 64) |
| Estimated weight, kg | 70 (46 to 85) | 70 (47 to 95) |
| Estimated body mass index, kg/m2 | 26 (18-29) | 24 (18-29) |
| Medical admission, n | 9 | 8 |
| APACHE II score on ICU admission | 22 (3 to 33) | 18 (5 to 34) |
| Mechanical ventilation on ICU admission | 9 | 7 |
| SOFA score on the first day of therapy | 11 (5 to 13) | 11 (2 to 15) |
| Time from ICU admission to ECMO, days | 3 (0 to 9) | NA |
| Time from ICU admission to vancomycin therapy, days | 7 (4 to 18) | 4 (0 to 8) * |
| Mechanical ventilation on the first day of therapy | 11 | 7 |
| Fluid balance (the day preceding the loading dose), mL/24 h | 1959 (−1404 to 5877) | 2153 (−1592 to 9686) |
| Albumin concentration (before the loading dose), g/dL | 2.6 (2 to 3.3) | 2.8 (2 to 3.8) |
| Protein concentration (before the loading dose), g/dL | 4.2 (2.8 to 4.8) | 4.6 (3.4 to 6.4) |
| Lactate level (before the loading dose), mmol/L | 1.1 (0.5 to 17.9) | 1.8 (0.7 to 7.9) |
| CrCl on the first day of therapy, mL/minute (n = 4) | 64 (39 to 99) | 61 (46 to 109) |
| CRRT intensity, mL/kg/h (n = 7) | 38 (19 to 53) | 42 (20 to 50) |
| Reason for ECMO initiation | ||
| Cardiogenic shock/ARDS/Sepsis, n | 5/4/2 | 2/4/5 |
| VA ECMO/VV ECMO, n | 5/6 | NA |
| Overall ICU mortality, n | 6 | 3 |
| Comorbidities | ||
| CVD | 2 | 1 |
| COPD/asthma | 3 | 2 |
| Diabetes | 3 | 2 |
| Previous serum creatinine >2.0 mg/dL | 1 | 0 |
| Liver disease | 0 | 1 |
| Solid organ transplant | 2 | 2 |
| Chronic immunosuppressive therapy | 3 | 3 |
| Neutropenia | 1 | 2 |
Data are presented as count or median (range). *P <0.05. APACHE, acute physiology and chronic health evaluation; SOFA, sequential organ failure assessment; CrCl, creatinine clearance; CRRT, continuous renal replacement therapy; VA ECMO, veno-arterial extracorporeal membrane oxygenation; VV ECMO, veno-venous extracorporeal membrane oxygenation; ARDS, acute respiratory distress syndrome; CVD, cardiovascular disease; COPD, chronic obstructive pulmonary disease; CRF, chronic renal failure; NA, not applicable.