Table 3.
Vancomycin serum concentrations and pharmacokinetics in the ECMO group and in the control group
| ECMO (n = 11) | Controls (n = 11) | |
|---|---|---|
| At T1 (4 h), mg/L | 51 (28 to 71) | 45 (37 to 71) |
| At T2 (12 h), mg/L | 23 (16 to 38) | 29 (21 to 35) |
| At T3 (24 h), mg/L | 20 (12 to 36) | 23 (17 to 28) |
| Vd, L | 99.3 (49.1 to 212.3) | 92.3 (22.4 to 149.4) |
| Total CL, L/h | 2.4 (1.7 to 4.9) | 2.3 (1.8 to 3.6) |
| AUC0–24, mg*h/L | 628 (537 to 840) | 698 (622 to 753) |
ECMO, extracorporeal membrane oxygenation; Vd, drug median volume of distribution; CL, drug clearance; AUC0–24, area under the curve of the first 24 hrs of therapy.