Table 2.

Adverse events at least possibly attributable to XmAb5574

Toxicity	0.3 mg/kg (N = 1)	1 mg/kg (N = 1)	3 mg/kg (N = 3)	6 mg/kg (N = 3)	9 mg/kg (N = 3)	12 mg/kg (N = 16)	Total (%)
Any event	1	1	3	3	2	14	24 (88.9)
DLTs
Grade 4 neutropenia lasting ≥7 d with febrile neutropenia						1	1 (3.7)
Other grade 3/4 toxicities
Neutropenia		1				1	2 (7.4)
Thrombocytopenia						2	2 (7.4)
Tumor lysis syndrome						1	1 (3.7)
Increased AST						1	1 (3.7)
Grade 1/2 toxicities occurring in >1 patient
Infusion reaction	1	1	1	2	2	11	18 (66.7)
Increased AST	1		2	1			4 (14.8)
Increased alanine aminotransferase			2	1		2	5 (18.5)
Neutropenia	1					1	2 (7.4)
Thrombocytopenia					1	2	3 (11.1)
Fever	1		1		1	1	4 (14.8)
Chills	1		1	1			3 (11.1)
Peripheral sensory neuropathy				1		2	3 (11.1)
Diarrhea				1		1	2 (7.4)
Flushing	1					1	2 (7.4)
Hyperuricemia			1			1	2 (7.4)
Hypocalcemia			1			1	2 (7.4)
Increased lipase			1			1	2 (7.4)