Table 4.
Mean (± SEM) scores on neuropsychological, neuropsychiatric and functional measures in the CBS and VHF-DLB groups
| Psychometric measures | CBS (number) | VHF-DLB (number) |
|---|---|---|
| General cognition | ||
| MMSE/30 (number =59) | 21.7 ± 1.2 (31) | 22.1 ± 1.1 (28) |
| Clock Drawing Test/10 (number =26) | 6.9 ± 0.8 (9) | 7.7 ± 0.6 (17) |
| NART/127.8 (number =38) | 107.5 ± 1.9 (19) | 108.4 ± 2.1 (19) |
| Raven’s Progressive Matrices (number =40) | 21.9 ± 1.6 (22) | 21.2 ± 1.3 (18) |
| DRS/144 (number =53) | 113.5 ± 4.1 (26) | 114.6 ± 3.7 (27) |
| Memory | ||
| CVLT Long Delay Free Recall/16 (number =46)a | 6.6 ± 0.6 (21) | 2.4 ± 0.5 (25) |
| CVLT Long Delay Cued Recall/16 (number =46)a | 7.4 ± 0.6 (21) | 3.9 ± 0.5 (25) |
| Delayed Visual Reproduction /41 (number =40b | 10.5 ± 2.3 (19) | 4.2 ± 1.2 (21) |
| Language | ||
| WAB total/100 (number =38) | 85.7 ± 2.5 (23) | 86.5 ± 2.2 (15) |
| Boston Naming/30 (number =47) | 24.0 ± 1.0 (22) | 22.5 ± 1.1 (25) |
| Semantic Fluency/20 (number =53) | 9.8 ± 1.2 (26) | 10.3 ± 1.0 (27) |
| Praxis | ||
| WAB praxis/60 (n =48) | 53.2 ± 1.6 (27) | 55.6 ± 0.6 (21) |
| Attention and working memory | ||
| Digit span - forward/12 (number =50) | 7.0 ± 0.6 (23) | 6.8 ± 0.5 (27) |
| Digit span - backward/12 (number =50) | 4.6 ± 0.6 (23) | 4.3 ± 0.5 (27) |
| Visuospatial abilities | ||
| Rey Osterieth Complex Figure/36 (number =45) | 17.0 ± 3.0 (20) | 18.5 ± 2.3 (25) |
| Benton Line Orientation /30 (number =44) | 13.2 ± 2.4 (21) | 13.4 ± 2.3 (23) |
| Executive functions | ||
| Phonemic (FAS) fluency (number =47) | 19.1 ± 2.7 (21) | 22.1 ± 3.2 (26) |
| Trail Making Test A (time in seconds) (number =42) | 108.7 ± 14.7 (19) | 101.4 ± 11.5 (23) |
| Trail Making Test B (time in seconds) (number =31) | 214.5 ± 39.7 (13) | 193.6 ± 20.9 (18) |
| WCST categories/6 (number =44) | (22) | (22) |
| Categories 0 to 1: Counts (%) | 11 (50%) | 17 (77%) |
| Categories 2 to 4: Counts (%) | 11 (50%) | 5 (23%) |
| WCST perseverative errors (number =44) | 11.7 ± 2.9 (22) | 19.8 ± 3.4 (22) |
| Neuropsychiatric features | ||
| Cornell Depression (number =54) | 22.8 ± 2.6 (30) | 16.0 ± 2.7 (24) |
| Neuropsychiatric Inventory/144 (number =55) | 12.1 ± 2.5 (29) | 10.5 ± 2.4 (26) |
| Functional measures | ||
| DAD (%) (number =57) | 68.8 ± 5.7 (30) | 78.9 ± 4.1 (27) |
a P <0.005; b P <0.05. The number of patients tested is listed next to individual measures. Missing data are secondary to the inability of the patient to complete the test. CBS, corticobasal syndrome; CVLT, California Verbal Learning Test; DAD, Disability Assessment Scale for Dementia; DRS, Mattis Dementia Rating Scale; FAS, F-, A-, and S-phonemic fluency; MMSE, Folstein’s Mini-Mental State Exam; NART, National Adult Reading Test; SEM, standard error of the mean; VHF-DLB, visual hallucination-free dementia with Lewy bodies; WAB, Western Aphasia Battery; WCST, Wisconsin Card Sort Test.