Table 5.
Areas of relative hypoperfusion on SPECT when CBS compared to their respective control groups
| Anatomical locus (Brodmann area) | Talairach coordinates | Number of voxels | SPM t-score ( P -value) | ||
|---|---|---|---|---|---|
| x | y | z | |||
| CBS versus controls (FWE-corr) | |||||
| Right middle frontal gyrus (6) | 50 | 8 | 42 | 236 | 5.4 (P =0.003) |
| Left superior frontal gyrus (6) | −18 | 9 | 70 | 99 | 5.4 (P =0.005) |
| CBS versus controls (FDR-corr) | |||||
| Right middle frontal gyrus (6) | 50 | 8 | 42 | 1791 | 5.4 (P =0.005) |
| Right superior frontal gyrus (6) | 6 | 7 | 70 | 4.7 (P =0.007) | |
| Right sub-gyrus (6) | 30 | −1 | 55 | 4.0 (P =0.014) | |
| Left superior frontal gyrus (6) | −18 | 9 | 70 | 850 | 5.4 (P =0.005) |
| Left superior frontal gyrus (6) | 0 | −2 | 68 | 3.5 (P =0.020) | |
| Left middle frontal gyrus (6) | −26 | −1 | 50 | 3.6 (P =0.019) | |
| Left precentral gyrus (9) | −34 | 9 | 31 | 203 | 4.4 (P =0.009) |
| Left precuneus (7) | −2 | −57 | 62 | 655 | 4.4 (P =0.009) |
| Right precuneus (7) | 4 | −53 | 65 | 4.4 (P =0.010) | |
| Left postcentral gyrus (7) | −4 | −51 | 67 | 3.7 (P =0.017) | |
| Left superior parietal lobule (7) | −34 | −53 | 60 | 834 | 4.1 (P =0.013) |
| Left superior parietal lobule (7) | −32 | −46 | 47 | 3.8 (P =0.017) | |
| Left postcentral gyrus (2) | −30 | −37 | 70 | 4.0 (P =0.015) | |
| Right postcentral gyrus (2) | 34 | −35 | 68 | 213 | 4.1 (P =0.013) |
| Right postcentral gyrus (2) | 48 | −27 | 40 | 163 | 3.9 (P =0.015) |
| Right inferior frontal gyrus (47) | 44 | 17 | −3 | 96 | 3.8 (P =0.016) |
| Right superior frontal gyrus (10) | 32 | 57 | 23 | 31 | 3.8 (P =0.017) |
| Right superior parietal lobule (7) | 32 | −59 | 58 | 67 | 3.7 (P =0.017) |
CBS, corticobasal syndrome; FDR-corr, corrected for False Discovery Rate; FWE-corr, corrected for Family-Wise Error; SPECT, single-photon emission computed tomography; SPM, Statistical Parametric Mapping.