Table 6.
Areas of relative hypoperfusion on SPECT when VHF-DLB is compared to their respective control group
| Anatomical locus (Brodmann area) | Talairach coordinates | Number of voxels | SPM t-score ( P -value) | ||
|---|---|---|---|---|---|
| x | y | z | |||
| VHF-DLB versus controls (FWE-corr) | |||||
| Left middle temporal gyrus (21) | −57 | −49 | −3 | 413 | 6.2 (P =0.000) |
| Right middle temporal gyrus (39) | 44 | −63 | 31 | 1292 | 5.9 (P =0.001) |
| Right superior parietal lobule (7) | 30 | −64 | 46 | 5.6 (P =0.003) | |
| Left precuneus (19) | −34 | −64 | 42 | 1195 | 5.9 (P =0.001) |
| Left superior temporal gyrus (39) | −48 | −57 | 27 | 5.7 (P =0.002) | |
| Left inferior parietal lobule (40) | −46 | −56 | 39 | 5.5 (P =0.004) | |
| Right middle temporal gyrus (21) | 61 | −35 | −10 | 211 | 5.4 (P =0.005) |
| Left middle occipital gyrus | −28 | −89 | −2 | 100 | 5.1 (P =0.013) |
| VHF-DLB versus controls (FDR-corr) | |||||
| Left middle frontal gyrus (21) | −57 | −49 | −3 | 33550 | 6.2 (P =0.000) |
| Left precuneus (19) | −34 | −64 | 42 | 5.9 (P =0.000) | |
| Right middle temporal gyrus (39) | 44 | −63 | 31 | 5.9 (P = 0.000) | |
| Right middle frontal gyrus (8) | 36 | 16 | 45 | 1743 | 3.9 (P =0.002) |
| Right middle frontal gyrus (9) | 36 | 27 | 37 | 3.9 (P =0.002) | |
| Right superior frontal gyrus (8) | 20 | 39 | 39 | 3.7 (P =0.003) | |
| Left medial frontal gyrus (11) | −4 | 61 | −15 | 144 | 3.7 (P =0.003) |
| Right inferior frontal gyrus (47) | 50 | 27 | −3 | 344 | 3.6 (P =0.004) |
| Left sub-lobar caudate | −14 | 10 | 5 | 41 | 3.4 (P =0.006) |
| Right superior frontal gyrus (9) | 14 | 52 | 25 | 23 | 3.2 (P =0.008) |
FDR-corr ,corrected for False Discovery Rate; FWE-corr, corrected for Family-Wise Error; SPECT, single-photon emission computed tomography; SPM, Statistical Parametric Mapping; VHF-DLB, visual hallucination-free dementia with Lewy bodies.