Table 2.
Drinking milestones in ever-drinkers before age 18 (N=1,550) |
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Models of first intoxication | Models of first DSM-5 symptom | |||
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Hazard ratio (95% CI) | χ2 p value | Hazard ratio (95% CI) | χ2 p value | |
Univariate model set | ||||
rs1229984a | 0.72 (0.56−0.91) | .006 | 0.69 (0.50−0.94) | .02 |
peer drinkingb | 1.89 (1.70−2.10) | <.0001 | 2.27 (1.98−2.60) | <.0001 |
Multivariate model set | ||||
rs 1229984 | 0.76 (0.61−0.96) | .02 | 0.73 (0.54−0.97) | .03 |
peer drinking | 1.88 (1.69−2.09) | <.0001 | 2.26 (1.97−2.60) | <.0001 |
Interaction model set | ||||
rs 1229984 | 0.56 (0.41−0.76) | .0002 | 0.45 (0.26−0.77) | .004 |
peer drinking | 1.81 (1.62−2.01) | <.0001 | 2.17 (1.88−2.50) | <.0001 |
rs1229984*peer drinking | 2.10 (1.32–3.32) | .002 | 2.29 (1.21–4.30) | .01 |
Examination of GxE term in interaction model set | ||||
None/few best friends drink (GA/AA vs GG) | 0.56 (0.41–0.76) | .0002 | 0.45 (0.26–0.77) | .004 |
Most/all best friends drink (GA/AA vs GG) | 1.16 (0.82–1.65) | .39 | 1.03 (0.73–1.45) | .87 |
Reference ADH1B rs1229984 genotype GG was compared to GA/AA;
Reference peer drinking status none/few best friends drink was compared to most/all best friends drink; All models adjusted for gender and ethnicity.