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. Author manuscript; available in PMC: 2014 Dec 5.
Published in final edited form as: Neuroimaging Clin N Am. 2009 Nov;19(4):517–526. doi: 10.1016/j.nic.2009.08.008

Fig. 2. Correlation of diffusion MRI changes with histopathological changes in a 9L brain tumor model treated with BCNU chemotherapy.

Fig. 2

(a) Haematoxylin and Eosin stained histology slides showing a decrease in cell density four days following chemotherapy. As the tumor repopulates, an increase in cell dencity at day 16 is observed (b) A plot of cell density as a function of time post-therapy. (c) Correlation of ADC as a function of tumor cell density. When changes in MR diffusion (mean ADC) are plotted against cell density at each of the time points, a significant correlation is observed, demonstrating that mean ADC is a quantitative surrogate for cell density. Courtesy of Chenevert et al. [34]