Table 2. Multivariable Model of Predictors of Early (6-month) Death or Re-transplant in Heart Transplant Recipients.
Predictor | Hazard Ratio | 95% Confidence Interval | P Value |
---|---|---|---|
Age at Transplant | ** | ** | <0.001 |
Recipient Height | ** | ** | <0.001 |
Donor Age | ** | ** | <0.001 |
Diagnosis (vs. Dilated CM) | |||
Ischemic CM | 1.22 | (1.14, 1.31) | <0.001 |
Hypertrophic CM | 1.36 | (1.02, 1.81) | 0.04 |
Congenital Heart Disease | 2.69 | (2.25, 3.22) | <0.001 |
Other | 1.29 | (1.13, 1.47) | <0.001 |
Drug Treated | 1.14 | (1.06, 1.23) | 0.001 |
Hypertension | |||
Mean PAP > 30 mmHg | 1.08 | (1.00, 1.16) | 0.06 |
PVR < 3 | 0.89 | (0.82, 0.96) | 0.002 |
Mechanical Ventilation | 2.41 | (2.12, 2.73) | <0.001 |
Intra-aortic Balloon Pump | 1.21 | (1.08, 1.36) | 0.001 |
VAD | 1.57 | (1.44, 1.72) | <0.001 |
ECMO | 2.10 | (1.44, 3.08) | <0.001 |
ICD | 1.09 | (1.00, 1.19) | 0.06 |
Ischemic Time | ** | ** | 0.001 |
PRA | |||
> 10% | 1.22 | (1.11, 1.33) | <0.001 |
Missing | 1.01 | (0.94, 1.09) | 0.81 |
Bilirubin at Transplant | ** | ** | 0.001 |
IV Antibiotic <2 Weeks Before Transplant Gender Match* | 1.24 | (1.12, 1.38) | <0.001 |
M recipient / F donor | 1.20 | (1.11, 1.30) | <0.001 |
F recipient / M donor | 1.11 | (0.99, 1.25) | 0.06 |
F recipient / F donor | 1.07 | (0.96, 1.20) | 0.24 |
Medicaid Insurance | 1.12 | (1.00, 1.25) | 0.06 |
Era (treated as linear 1-5) | 0.83 | (0.80, 0.87) | <0.001 |
Race (vs. White) | |||
Black | 1.15 | (1.05, 1.26) | 0.004 |
Hispanic | 1.03 | (0.90, 1.18) | 0.66 |
Restricted cubic splines, with a separate term to identify missing values if required. CM (Cardiomyopathy), PAP (Pulmonary Artery Pressure), PVR (Pulmonary Vascular Resistance), ECMO (Extra-corporeal Membrane Oxygenation), ICD (Implantable Cardioverter Defibrillator), VAD (Ventricular Assist Device), hr (hour), IV (intravenous), PRA (Panel Reactive Antibodies),
The reference category is M recipient-M donor. The donor-recipient BMI ratio or donor LV ejection fraction was not significant.