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Enpp1−/− mice exhibit insulin sensitization. (A) Glucose tolerance test (GTT). (B) Glucose-stimulated insulin secretion (GSIS). (C) Insulin tolerance test (ITT) represented as percentage (%) of basal glucose. (D) Metabolic tests analyzed as area under the curve. Mice were reared under control dietary conditions to 16 weeks of age. Results are presented as mean±s.e.m. (n=8). *P<0.05.
