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. 2014 Oct 31;7(12):1341–1350. doi: 10.1242/dmm.017905

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Enpp1^−/− mice show improved insulin tolerance in response to a chronic HFD challenge. (A) Glucose tolerance test (GTT). (B) Glucose-stimulated insulin secretion (GSIS). (C) Insulin tolerance test (ITT) represented as percentage (%) of basal glucose. Mice were reared under high-fat dietary conditions and were 16 weeks of age. Results are presented as mean±s.e.m. (n=7). *P<0.05. (D) Metabolic tests analyzed as area under the curve. (E) Number of islets. (F) Size of islets. Results are presented as mean±s.e.m. *P<0.05.