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. 2014 Dec 5;5:671. doi: 10.3389/fmicb.2014.00671

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Copyright © 2014 Shrestha, Chang, Meissner, Oblad, Shrestha, Sorensen, Grilley and Takemoto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of K20 on C. neoformans H99 infectivity in a RAG^−/− mouse model. (A) Mouse lung fungal burden at day 15 after infection with C. neoformans H99 cells mixed (black bar) or not mixed (white bar) with K20. Fungal burdens were assessed by plating lung homogenate suspensions for CFU determinations. Control treatment with K20 and no cells (gray bar) showed no fungal burden. ^*** Indicates a p-value < 0.001 determined by One-Way ANOVA. Light microscopic images of lung homogenates were prepared from C. neoformans H99 infected mice with no K20 (B) and with K20 (C) exposure. Methanol-fixed homogenates on glass slides were stained with Diff-Quik™. Yeast cells were visible as large purple colored cells surrounded by an opaque halo.