TABLE II.

Most common adverse events with sunitinib 37.5 mg by continuous daily dosing

Event	Event occurrence (%)
	Escudier et al., 200926 (rcc)	George et al., 200921 (gist)	Novello et al., 200928 (nsclc)	Raymond et al., 201127 (pancreatic net)
Diarrhea	75	40	34	59
Nausea	37	27	40a	45
Asthenia	79b	37	60b	34
Vomiting	27	23	40a	34
Fatigue	79b	33	60b	32
Hair colour change	34	22	—	29
Neutropenia	45	57	9c	29
Abdominal pain	23	18	—	28
Hypertension	44	28	28	26
Hand–foot syndrome	49	25	—	23
Anorexia	42	20	17	22
Stomatitis	89	22	32d	22
Dysgeusia	36	—	21	20
Erythema	17	—	21	—

^aNausea and vomiting combined.

^bAsthenia and fatigue combined.

^cOnly grade 3 and higher reported.

^dStomatitis and mucosal inflammation.

net = neuroendocrine tumour; gist = gastrointestinal stromal tumour; rcc = renal cell cancer; nsclc = non-small-cell lung cancer.