TABLE I.

Primary angiosarcoma of the ovary reported in the literature

Reference	Case id	Age (years)	Clinical manifestations	Stage	Histology	Treatment		Follow-up
						Primary	Adjuvant
Ongkasuwan et al., 19824	1	77	Abdominal distention	iii	Mucinous cyst adenoma and angiosarcoma	Right salpingo-oophorectomy	None	Died of disease (2 months)
Patel et al., 19915	2	42	Abdominal pain	iv	Angiosarcoma	Right salpingo-oophorectomy	None	Died of disease (18 days)
Cunningham et al., 19946	3	19	Abdominal discomfort	iv	Angiosarcoma	Left salpingo-oophorectomy, omentectomy, and para-aortic lymph node biopsy	Ifosfamide, doxorubicin	Died of disease (7 months)
Nara et al., 19967	4	33	Hemoptysis	iv	Angiosarcoma	Lung biopsy	None	Died of disease (2 months)
Nielsen et al., 19978	5	20–32	Abdominal pain	i	Angiosarcoma	Not available	Not available	No evidence of disease (5.5 years)
	6		Abdominal pain	i	Angiosarcoma	Not available	Not available	No evidence of disease (9 years)
	7		Abdominal pain	i	Angiosarcoma	Not available	Not available	Not available
	8		Abdominal pain	i	Angiosarcoma	Not available	Not available	Not available
	9		Abdominal pain	iii	Angiosarcoma	Not available	Not available	Died of disease (2 months)
	10		Abdominal pain	iii	Dermoid cyst and angiosarcoma	Not available	Not available	Died of disease (15 months)
	11		Abdominal pain	iii	Dermoid cyst and angiosarcoma	Not available	Not available	Died of disease (30 months)
Furihata et al., 19989	12	46	Abdominal mass and discomfort	i	Angiosarcoma	Total abdominal hysterectomy bilateral salpingo-oophorectomy, and pelvic lymphadenectomy	Cisplatin, para-aortic radiation therapy	Died of disease (9 months)
Lifschnitz–Mercer et al., 199810	13	25	Abdominal pain	iii	Angiosarcoma	Left salpingo-oophorectomy,	Ifosfamide, doxorubicin	Recurrent disease (18 months)
Nucci et al. 199811	14	35	Palpable ovarian mass	iv	Angiosarcoma	Salpingo-oophorectomy	None	Died of disease (“quickly”)
	15	25	Abdominal pain	iii	Angiosarcoma	Left salpingo-oophorectomy,	Chemotherapy	No evidence of disease (3 months)
	16	42	Hemoperitoneum	i	Angiosarcoma	Salpingo-oophorectomy	None	Died of disease (2 years)
	17	27	Abdominal pain	i	Angiosarcoma	Right salpingo-oophorectomy,	None	No evidence of disease (14 months)
Jylling et al., 199912	18	37	Cyst	i	Mucinous cystadenocarcinoma and angiosarcoma	Right oophorectomy	Not available	Not available
Platt et al., 199913	19	40	Abdominal pain	iv	Angiosarcoma	Optimal debulking	Mesna, doxorubicin, ifosfamide, dacarbazine	No evidence of disease (2 months)
Twu et al., 199914	20	38	Hemoptysis	iv	Angiosarcoma	Full staging, debulking	Ifosfamide, doxorubicin	Died of disease (7 months)
Pillay et al., 200115	21	45	Abdominal distention	iv	Borderline serous cystadenocarcinoma and angiosarcoma	Suboptimal debulking	None	Died of disease (3 months)
Davidson and Abeler, 200516	22	19	Abdominal pain	iii	Angiosarcoma	Left ovariectomy	Doxorubicin, ifosfamide, explorative laparotomy, radiation therapy	Died of disease (1 year)
Quesenberry et al., 200517	23	31	Abdominal distention	ic	Angiosarcoma	Full staging	Mesna, doxorubicin, ifosfamide, dacarbazine	No evidence of disease (10 months)
Jha et al., 200518	24	28	Abdominal pain	i	Angiosarcoma	Right salpingo-oophorectomy,	Complete re-debulking, ifosfamide, doxorubicin	No evidence of disease (6 years)
den Bakker et al., 200619	25	30	Abdominal pain	iii	Dermoid cyst and angiosarcoma	Left salpingo-oophorectomy, staging, and subtotal omentectomy	Chemotherapy, debulking	Died of disease (9 months)
Contreras and Malpica, 200920	26	32	Bloating, abdominal pain	iv	Dermoid cyst and angiosarcoma	Total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and appendectomy	Ifosfamide, doxorubicin	Died of disease (29 months)
Bradford et al., 201021	27	67	Bloating, fatigue, abdominal pain	iiic	Angiosarcoma	Full staging, debulking	None	Died of disease (1 month)
Cambruzzi et al., 201022	28	65	Sensation of heaviness in the hypogastrium	i	Ovarian fibroma and angiosarcoma	Exploratory laparotomy	Chemotherapy	No evidence of disease (2 months)
Serrano et al., 201023	29	23	Abdominal pain	iiic	Angiosarcoma	Optimal debulking	Epirubicin, ifosfamide	No evidence of disease (12 months)
Iljazovic et al., 201124	30	11	Left hip pain	iia	Angiosarcoma	Tumourectomy, bilateral salpingo-oophorectomy, and partial omentectomy	Ifosfamide, actinomycin, vincristine, omentectomy, and lymphadenectomy	No evidence of disease (10 months)
Aragon et al., 201125	31	39	Abdominal girth	iv	Mucinous cyst adenoma and angiosarcoma	Total abdominal hysterectomy, bilateral salpingo-oophorectomy,	None	Died of disease (3 months)
Bosmuller et al., 201126	32	81	Abdominal pain and distention	i	Angiosarcoma	Total abdominal hysterectomy, right salpingo-oophorectomy,	Doxorubicin	No evidence of disease (5 months)
Takahashi et al., 201227	33	59	Acute abdominopelvic pain	Not avail-able	Clear cell carcinoma, dermoid cyst, and angiosarcoma	Total abdominal hysterectomy, bilateral salpingo-oophorectomy, infracolic omentectomy	Paclitaxel, platinum	Not available
Guseh et al., 201328	34	40	Fatigue and nausea	iiic	Angiosarcoma	Total abdominal hysterectomy, bilateral salpingo-oophorectomy,	Ifosfamide, doxorubicin	Recurrent disease
Yaqoob et al., 201429	35	41	Abdominal pain and vaginal bleeding	ia	Angiosarcoma	Left salpingo-oophorectomy, incisional biopsy of right ovary	None	Not available