Figure 4. Enhanced mineralization in asj-2J mice placed on “acceleration diet”, rich in phosphate and low in magnesium.

The mice were placed on this diet at 4 weeks of age and necropsy was performed at 12 weeks. Note extensive mineralization as visualized by special stain (Alizarin Red). Assessment of the histopathology suggested that the mineralization was more extensive in mice kept on acceleration diet compared to the same mice kept on control diet (compare mineralization in Fig. 1B).