Table 3.
Summary of the covariate model steps
| Step | Covariate–parameter relationship | ΔOFV1 |
|---|---|---|
| 1 (forward inclusion)2 | CYP2D6-inferred metabolic status on CL/F | −148 |
| 2 (forward inclusion) | Age on CL/F | −75 |
| 3 (forward inclusion) | Height on V2/F | −63 |
| 4 (backward deletion) | >7.88 |
1
Change in objective function value (OFV) value compared to previous step.
2
CYP2C19-inferred metabolic status was highly correlated with CL/F in the first forward-inclusion step, with a drop of 72 points in OFV; but this relationship was not further evaluated in the next covariate model step due to over-parameterisation.