Table 4. Multiple linear regression analysis of variables including serum bilirubin for carotid intima-media thickness within each gender.
| Men N = 325 | Women N = 509 | |||
| Multiple linear regression analysis | Multiple linear regression analysis | |||
| Model 1 | Model 2 | Model 1 | Model 2 | |
| Characteristics | β(P-value) | β(P-value) | β(P-value) | β(P-value) |
| Age | 0.199 (0.002) | 0.232 (<0.001) | 0.186 (<0.001) | 0.168 (<0.001) |
| Body mass index | −0.064 (0.312) | – | 0.071 (0.123) | – |
| Smoking status | 0.154 (0.006) | 0.155 (0.004) | 0.069 (0.101) | – |
| Systolic blood pressure | 0.072 (0.331) | 0.106 (0.047) | 0.104 (0.046) | – |
| Diastolic blood pressure | 0.059 (0.420) | – | −0.148 (0.004) | – |
| Antihypertensive medication (No = 0, Yes = 1) | 0.087 (0.125) | – | 0.126 (0.004) | 0.115 (0.007) |
| Triglycerides | −0.008 (0.906) | – | −0.050 (0.317) | – |
| HDL cholesterol | −0.084 (0.144) | – | −0.044 (0.331) | – |
| LDL cholesterol | 0.029 (0.619) | – | 0.081 (0.086) | – |
| Antidyslipidemic medication (No = 0, Yes = 1) | −0.027 (0.627) | – | −0.083 (0.054) | – |
| Fasting plasma glucose | 0.039 (0.519) | – | 0.135 (0.003) | 0.134 (0.002) |
| Antidiabetic medication (No = 0, Yes = 1) | 0.021 (0.723) | – | −0.031 (0.497) | – |
| eGFR | −0.057 (0.324) | – | 0.074 (0.104) | – |
| Alanine aminotransferase | −0.019 (0.750) | – | 0.007 (0.877) | – |
| Gamma-glutamyltransferase | −0.139 (0.039) | −0.136 (0.016) | −0.104 (0.032) | −0.122 (0.005) |
| Serum bilirubin | -0.041 (0.461) | – | −0.119 (0.006) | −0.107 (0.011) |
| Cardiovascular disease | 0.133 (0.022) | 0.131 (0.014) | 0.103 (0.017) | 0.093 (0.031) |
| R2 | 0.157 (<0.001) | 0.132 (<0.001) | 0.153 (<0.001) | 0.113 (<0.001) |
β, standardized coefficient; R2, multiple coefficient of determination. Model 1, forced entry method and Model 2, forward stepwise method. Data for triglycerides, fasting plasma glucose, alanine aminotransferase, gamma-glutamyltransferase, and serum bilirubin were skewed and log-transformed for analysis.