Table 6.
Study 2 (Ethiopia): VL sensitivity, specificity, PPV and NPV for DAT and four rK28 RDTs using human sera
| Test | Sensitivity | Specificity* | Specificity† | PPV* | PPV† | NPV* | NPV† |
|---|---|---|---|---|---|---|---|
| Percentage (95% confidence interval) | |||||||
| DAT | 95.9 (89.9–98.8) | 97.7 (93.5–99.5) | 100 (92.7–100) | 96.9 (91.3–99.3) | 100 (96.1–100) | 97.0 (92.5–99.1) | 92.4 (81.7–97.9) |
| DPP | 99.0 (94.5–99.9) | 83.3 (76.2–89.0) | 94.0 (83.4–98.7) | 80.4 (72.3–87.0) | 97.0 (92.7–100) | 99.1 (95.4–99.9) | 97.9 (88.9–99.9) |
| CTK | 98.0 (92.9–99.7) | 94.4 (89.3–97.5) | 100 (92.8–100) | 92.4 (85.6–96.6) | 100 (96.3–100) | 98.5 (94.8–99.8) | 96.1 (86.7–99.5) |
| EMT | 98.0 (92.9–99.7) | 81.9 (74.6–87.8) | 98.0 (89.3–99.9) | 79.0 (70.8–85.8) | 98.9 (94.5–99.9) | 93.6 (87.8–97.2) | 96.0 (81.7–97.9) |
| InBios+ | 96.0 (90.0–98.9) | 80.5 (73.1–86.6) | 98.0 (89.3–99.9) | 77.4 (69.0–84.4) | 98.9 (94.3–99.9) | 96.6 (91.6–99.0) | 92.4 (81.7–97.9) |
*
Values calculated using HNEC and OD serum samples.
†
Values calculated using only HNEC serum samples.
VL = visceral leishmaniasis; PPV = positive predictive value; NPV = negative predictive value; DAT = direct agglutination test; RDTs = rapid diagnostic tests; DPP = dual path platform; EMT = EASE-Medtrend test.