Table 14.
Characteristics of dengue infection in persons inoculated with Hawaii DENV-1 intranasally compared with persons inoculated by mosquito bite or injection of infected serum*
| Characteristic | DENV-1 Hawaii (n = 93) | DENV-1 Hawaii intranasally (n = 6) | P for standard route vs. intranasal |
|---|---|---|---|
| Days to fever onset | 6.4 (5.6–7.8) | 11.0 (9.3–11.9) | 0.001 |
| Maximum temperature (°C) | 39.6 (39.2–39.8) | 38.8 (38.2–39.3) | 0.028 |
| Fever duration (days > 38°C) | 3.4 (2.2–4.5) | 1.1 (0.7–3.1) | 0.071 |
| Days to leukopenia onset | 8.0 (7.0–9.0) | 10.5 (9.3–11.8) | 0.009 |
| Minimum WBC count/μL | 3,100 (2,525–3,600) | 3,350 (2,663–3,663) | 0.764 |
| Leukopenia duration (days < 4,500) | 4.0 (2.5–5.0) | 2.8 (1.0–3.8) | 0.088 |
*
Values are median (interquartile range). P values were calculated by using Wilcoxon's rank sum test. Values in bold are statistically significant.