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. 2014 Dec 5;9(12):e114722. doi: 10.1371/journal.pone.0114722

Table 1. Deduced ORFs and their predicted functions in the ascamycin/dealanylascamycin gene cluster.

Gene Product size Purposed function Closest relative, origin, accession number %identity
orf(-1) 350 transposase Orf3, Streptomyces rishiriensis, AAR11882 69
acmA 320 Sulfate adenylyltransferase subunit 2 MmcV, Streptomyces lavendulae, Q9X5U0 80
acmB 179 adenylylsulfate kinase OrfQ, Streptomyces sp. AM-7161, BAC79014 67
acmC 414 major facilitator superfamily protein Micromonospora sp. CNB394, WP_018786560 29
acmD 871 alanyl-tRNA synthetase M901_2280, Bacteriovorax sp. DB6_IX, EQC50866 44
acmE 455 esterase Xanthomonas campestris, BAA11623 20
acmF 370 alanyl-tRNA synthetase CGL2_10933004, Leptospirillum sp. Group II '5-way CG', EDZ38785 27
acmG 480 Sulfatase Francci3_1756, Frankia sp. CcI3, YP_480861 47
acmH 453 Radical SAM domain/B12 binding domain-containing protein MCON_2786, Methanosaeta concilii, YP_004384990 24
acmI 302 acylsulfatase Streptomyces sp. CNB091, WP_018955485 69
acmJ 557 Putative Fe-S oxidoreductase Streptomyces clavuligerus, WP_003962555 79
acmK 356 sulfotransferase SGR_905, Streptomyces griseus, YP_001822417 59
acmL 250 methyltransferase UbiE, Leifsonia rubra CMS 76R, EPR77097 30
acmM 142 hypothetical protein BN159_7117, Streptomyces davawensis, YP_007525623 77
acmN 319 amidinotransferase Francci3_1759, Frankia sp. CcI3, YP_480864 57
acmO 444 hypothetical protein Francci3_1760, Frankia sp. CcI3, YP_480865 54
acmP 658 DNA topoisomerase II Francci3_1761, Frankia sp. CcI3, YP_480866 68
acmQ 155 rubrerythrin Francci3_1762, Frankia sp. CcI3, YP_480866 54
acmR 438 major facilitator superfamily protein Streptomyces sp. W007, WP_007453428 53
acmS 395 hypothetical proteins Streptomyces griseus, WP_003963977 31
acmT 220 phosphatase Streptomyces sulphureus, WP_019549800 52
acmU 418 sodium/hydrogen antiporter flH, Streptomyces cattleya, CAJ20009 28
acmV 194 adenine phosphoribosyl-transferase Streptomyces albulus, WP_016574607 58
acmW 451 sulfate adenylyltransferase large subunit Azi10, Streptomyces sahachiroi, ABY83149 78
orf(+1) 323 oxidoreductase Streptomyces scabrisporus, WP_020552419 85
acmX 449 flavin-dependent halogenase ChlB4, Streptomyces antibioticus, AAZ77674 65
acmY 438 flavin-dependent halogenase ChlB4, Streptomyces antibioticus, AAZ77674 57