Table 2. A. Brain Regions that Show Significant Relative Atrophy in Relation to the Presence of Hallucinations in AD patients.
| Coordinates (mm, MNI) | |||||||||
| Brain regions | BA vicinity | Side | No. Voxels | T value | x | y | z | p | |
| A | Insula, anterior part and inferior frontal gyrus (GM) | 13/45/47 | R | 594 | 4.13 | 45 | 28 | 6 | 0.000047 |
| Frontal lobe, superior frontal gyrus (GM) | 6 | L | 70 | 3.72 | −9 | 27 | 61 | 0.00019 | |
| Occipital lobe, lingual gyrus (WM) | 18 | R/L | 113 | 3.62 | 7.5 | −86 | −4 | 0.00026 | |
| B | Frontal lobe, precentral gyrus (GM) | 6 | R | 86 | 4.52 | 37 | −8 | 32 | 0.0000034 |
| Insula, anterior part (GM) | 13 | R | 75 | 3.77 | 34 | 10 | 14 | 0.00003 | |
| Temporal lobe, superior temporal gyrus (GM) | 21 | R | 69 | 4.02 | 51 | −6 | −13 | 0.00010 | |
| Parietal lobe, precuneus (WM) | 7 | L | 63 | 4.37 | −14 | −57 | 71 | 0.0000053 | |
T = p<0.001, uncorrected, minimum cluster size = 25 voxels; BA = Brodmann's area; L = left; GM = gray matter; No. = number; R = right; sup. = superior; WM = white matter.
AD patients with hallucinations have been compared to matched (age, sex, handedness, educational level and MMSE) AD patients without hallucinations. B. Correlation between Hallucination Intensity (NPI-Q) and Regional Brain Volume (MRI). Underlined brain regions are “core regions” of hallucinations in AD (see Methods).