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Abiraterone increases steroids with mineralocorticoid activity upstream of CYP17A1. Shown are median serum levels of corticosterone and deoxycorticosterone over time in patients with metastatic castration-resistant prostate cancer who received abiraterone acetate at doses of 250 to 2,000 mg daily. The right panel shows mean corticosterone levels at day 28 by abiraterone acetate dose [12].
