Figure 5.

Dexamethasone (0.5 mg/day) suppresses abiraterone-mediated increases in adrenocorticotropic hormone (ACTH). Abiraterone acetate treatment (n = 26) was associated with a significant increase in median plasma ACTH levels from 17 pg/mL to 124 pg/mL (660% increase). This rise in ACTH was suppressed to below the lower limit of sensitivity (10 pg/mL) after administration of oral dexamethasone 0.5 mg/day for <14 days. Normal ACTH levels in adults (mean ± SE): 28.7 ± 12 [13, 17].

Abbreviations: ACTH, adrenocorticotropic hormone; LLOS, lower limit of sensitivity; Rx, treatment.