Table 5.

Interactions between SNPs and environmental determinants of asthma age-of-onset

Environmental determinant	SNP	Risk allele	Gene	Position	Interaction test
					t-Statistic	P-value
						Uncorrected	Correcteda
Carpet exposure	rs4129267	T	IL6R	1q21.3	−2.215	0.0275	0.9740
Paternal smoking	rs10508372	C	LOC338591	10p14	−2.523	0.0122	0.8000
	rs9500927	T	HLA-DOA	6p21.32	2.151	0.0322	0.9865
Direct exposure to paternal smoking	rs10508372	C	LOC338591	10p14	−2.564	0.0108	0.7627

^aP-value is corrected for multiple testing by 10,000 permutations.